ResearchThe computational biology research group develops new computational methods, efficient algorithms, and powerful software tools to help answer fundamental biological questions. We are especially interested in problems related to understanding the evolution of genes, genomes, and species. Some of our specific projects include:
- Inferring gene family and genome evolution through gene duplication, horizontal transfer, and loss.
- Understanding evolution at the sub-gene/domain level.
- Reconstructing highly accurate gene trees in both eukaryotes and prokaryotes for evolutionary and functional genomic studies.
- Building whole-genome and multi-locus species phylogenies.
Open PositionsPhD positions: Positions are available in the computational biology group for bright and motivated PhD students. Please click here for further details.
Research opportunities for undergraduate students: Positions are also available for motivated undergraduate students who wish to gain research experience by working on exciting research problems. Please click here for further details.
March 2016: Undergraduate lab member Soumya Kundu's research paper on the impact of uncertain gene tree rooting on DTL reconciliation accepted to ISBRA 2017.
December 2016: Undergraduate lab member Soumya Kundu selected to UConn's University Scholar Program in support of his research on gene tree rooting.
October 2016: Mukul invited for plenary talk at the IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) in Atlanta, USA. Slides from the talk are available here.
September 2016: Research project on "Algorithmic Techniques for Inferring Transmission Networks" gets funded by NSF.
September 2016: Research project on "Integrating the geological and genomic records" gets funded by NSF.
August 2016: Research project on "Understanding Horizontal Gene Transfer in Bacteria and Archaea" gets funded by NSF.
July 2016: Mukul named UTC professor of engineering innovation for excellence in research.
July 2016: Paper on exact algorithms for DTL-reconciliation with non-binary gene trees accepted to ACM-BCB.
March 2016: Undergraduate lab member Soumya Kundu receives UConn SURF award to support his research in Summer 2016.
February 2016: Mukul awarded NSF CAREER award to support research on domain-level evolution of gene families.
December 2015: Full version of paper on NP-completeness of DTL-reconciliation with non-binary gene trees to be published in TCBB.
March 2015: Paper on NP-completeness of DTL-reconciliation with non-binary gene trees accepted to ISBRA.
February 2015: Paper on Roadmap Epigenomics consortium's integrative analysis of 111 reference human epigenomes appears in Nature.
December 2014: Paper on microbial gene tree error-correction accepted to Bioinformatics.
November 2014: Paper on Mouse ENCODE consortium's comparative analysis of the mouse genome appears in Nature.
June 2014: Undergraduate research assistant James Boivie joins the group. Welcome!
April 2014: Paper on Pareto-optimal DTL reconciliation accepted to ISMB.
January 2014: PhD student Misagh Kordi joins the group. Welcome!
November 2013: Paper on Duplication-Loss-Coalescence reconciliation to appear in Genome Research.
August 2013: PhD student Lei Li joins the group. Welcome!